Table 4.
Activity of the studied compounds (10 µM, seven days of incubation) against T. cruzi (Y strain) infection of H9C2 (monolayers and spheroids). The parasite load was determined by light microscopy and qPCR quantification.
| Compound | % of Death Rate by Light Microscopy Quantification | % of Death Rate by qPCR 3D |
|
|---|---|---|---|
| 2D | 3D | ||
| Bz | 100 | 98.4 (98.1 to 98.7) | 100 |
| FH11706 (1) | 99.25 (98.83 to 99.67) | 91.6 (86.2 to 97) | 85 (79 to 91) |
| FH10714 (2) | 100 | 93.5 (93.46 to 93.54) | 67 (38 to 96) |
| FH8513 (3) | 99.14 (97.9 to 100) | 83.8 (67.5 to 100) | 94 (90 to 98) |
Values are the average of two independent determinations; 95% of confidence intervals are indicated.