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. 2022 Nov 12;14(22):4789. doi: 10.3390/nu14224789

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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IL-22R-p-STAT3 pathway mediated by IL-22 secretion of LPMCs in ISC proliferation after L-Fucose treatment. Representative immunofluorescence images of (A) IL-22R (red), Lgr5 (green) and (B) p-STAT3 (green) in organoids (scale bar, 100 μm). Quantitative analysis of (C) Lgr5, (D) IL-22R and (E) p-STAT3 fluorescence intensity in organoids. (F) Western blotting analysis of Lgr5, β-catenin, p-STAT3 and STAT3 in organoids. (G) qRT-PCR analysis of IL-22R in organoids. (H) ELISA analysis of IL-22 in the culture supernatant of the LPMC -organoid coculture system. Data are expressed as the mean ± SD. * p < 0.05, ** p < 0.01, **** p < 0.0001; NS, no significance. +, with. −, without.