Table 1.
The molecular signature of G-1 resembles to that of microtubule-targeting agents. The Cmap approach was used, allowing identification of the top molecules (tau > 90) whose molecular signatures are close to those of G-1 after 72 h of treatment with 1 µM of the U251 cell line.
| Id | median_tau_score | Name | Belongs to |
|---|---|---|---|
| BRD-K91145395 | 98.86 | prostratin | PKC activator |
| BRD-K12539581 | 98.48 | nocodazole | tubulin inhibitor |
| BRD-K86003836 | 98.31 | flubendazole | tubulin inhibitor |
| BRD-K10916986 | 98.31 | vinorelbine | tubulin inhibitor |
| BRD-A76528577 | 98.10 | vincristine | tubulin inhibitor |
| BRD-K77987382 | 97.63 | mebendazole | tubulin inhibitor |
| BRD-K37456065 | 97.37 | VU-0365114-2 | M5 modulator |
| BRD-K91623615 | 97.33 | ABT-751 | tubulin inhibitor |
| BRD-K94325918 | 96.28 | kinetin-riboside | antiproliferative and apoptosis inhibitor |
| BRD-A54927599 | 96.17 | KF-38789 | P-selectin-mediated cell adhesion inhibitor |
| BRD-K35687265 | 95.98 | ON-01910 | PLK inhibitor |
| BRD-A55594068 | 95.91 | vinblastine | tubulin inhibitor |
| BRD-K59753975 | 95.71 | vindesine | tubulin inhibitor |
| BRD-K36055864 | 94.89 | cycloheximide | protein synthesis inhibitor |
| BRD-K01976263 | 94.67 | emetine | Wnt/β-catenin inhibitor |
| BRD-A52650764 | 94.47 | ingenol | PKC activator |
| BRD-K99498722 | 91.02 | NPI-2358 | tubulin inhibitor |