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. 2022 Nov 18;23(22):14349. doi: 10.3390/ijms232214349

Figure 4.

Figure 4

Transcriptional profile of 2D-MSCs and 3D-MSCs cultured in inflammatory or non-inflammatory conditions. (A) TSG-6, TGF-β1, IL-10, TNF-α, STAT1, JAK1, and JAK3 expressions in 2D-MSCs and 3D-MSCs exposed to a non-inflammatory medium. Cells did not express IDO and PD-L1 when in a non-inflammatory medium. (B) TSG-6, TGF-β1, IL-10, TNF-α, STAT1, JAK1, JAK3, IDO, and PD-L1 expressions in 2D-MSCs and 3D-MSCs exposed to an inflammatory medium. The median Ct values obtained 2D-MSCs were used as a reference. (C) Radial plot demonstrating the differences in overall transcripts between 2D-MSCs and 3D-MSCs cultured in inflammatory or non-inflammatory conditions. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.