Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 31;10(11):660. doi: 10.3390/toxics10110660

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Differential cytotoxicity among oral epithelial cells upon treatment with different flavored oral smokeless nicotine products: (A) Diagrammatical representation of the experimental workflow. (B–D) Cytotoxicity Assay on oral epithelial cells: human gingival epithelium progenitors cells (HGEPp; gingival epithelial cells) were treated with different doses (0.25%, 0.5%, 1%, 3%, and 10%) of oral nicotine extracts categorizing natural/synthetic tobacco, menthol, and fruit flavors from different brands (Snus, Zyn, Grizzly, Lucy and ON). Followed by 24 h exposure, conditioned media were used for the lactate dehydrogenase (LDH) assay. Data represented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001 compared to control. n = 3.