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. 2022 Oct 31;10(11):660. doi: 10.3390/toxics10110660

Figure 7.

Figure 7

Inflammatory mediator response by oral nicotine products in oral epithelial cells: HGEPp cells were treated at oral nicotine pouches extracts categorized with natural/synthetic tobacco, menthol, and fruit flavors) of different brands (Snus, Zyn, Grizzly, Lucy, and ON). Following 24 h exposure, conditioned media was used to perform ELISAs. (A) Protein levels of TNF-α determined by ELISA. (B) Protein levels of IL-6 determined by ELISA. (C) Protein levels of IL-8 determined by ELISA. Data represented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001 compared to negative control (untreated) n = 3.