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. 2022 Oct 31;10(11):660. doi: 10.3390/toxics10110660

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inflammatory mediator response due to flavoring nicotine oral products in bronchial epithelial cells. (A) BEAS-2B cells were treated with spearmint-flavored nicotine pouches from Zyn and Skoal brands. Following 24 h exposure, conditioned media was used for IL-8 measurements. (B) 16HBE cells were treated with different oral nicotine pouch flavors ON! original, Rogue mango, or Velo black cherry and incubated for 24 h. Following 24 h exposure, conditioned media was used for IL-6 measurement. Results are represented graphically.