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. 2022 Oct 31;10(11):660. doi: 10.3390/toxics10110660

Figure 9.

Figure 9

Schematic demonstration of the effect of Oral Nicotine Pouch on Oral/lung Epithelial Cells. Chewing of Oral Nicotine Pouch could lead to oral epithelial injury by releasing ROS via activation of inflammatory cytokines such as TNF-α, IL-6, and IL-8 which could further lead to oral and lung-related problems.