Skip to main content
. 2022 Nov 15;14(22):4833. doi: 10.3390/nu14224833

Table 1.

Effects of mushroom polysaccharides on NDs.

Mechanism Source (Latin Name) Polysaccharide Molecular Weight (kDa) Monosaccharide Composition Cell Lines/Model Type of NDs Potential Mechanism Year/References
Anti-oxidant activities Inonotus obliquus IOPS 111.9 / L-Glu damaged HT22 cells; APP/PS1 mice AD Regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects 2019
[61]
IOP / / Tacrine-induced HepG2 cells AD Inhibition of ROS generation, 8-OHdG formation in mitochondrial DNA, and loss of the mitochondrial transmembrane potential, decrease in the cytochrome c release and activation of caspase-3 2019
[90]
Ganoderma lucidum GLP 15.0 / APP/PS1 mice AD Reduce Aβ deposits, increase protein levels of p-FGFR1, p-ERK and p-Akt, potentiate FGFR pathways 2017
[63]
GLA / Gal and Glc (1.0:8.3) 25-35- or Aβ42-exposed rat primary cortical neurons AD Antagonize Aβ peptide neurotoxicity, inhibit JNK, ERK and p38 MAPK pathways 2008
[64]
GLP / / Kainic acid-treated Wistar rats Epilepsy Inhibit calcium overloading and ERK1/2 and NF-κB expression; stimulate CaMK II α and Cav-1 expression 2015
[65]
Ganoderma atrum PSG-1 1013 Man, Gal and Glc (1:1.28:4.91) D-Gal-treated Kunming mice Aging Decrease MDA and GSSG levels, increase SOD, CAT, GPx and GSH activities in liver, brain and spleen 2012
[56]
Dictyophora indusiata DiPS / Man, Fuc, Glc, Gal, Rha, Glc-UA and Xyl (86.8:4.5:3.9:1.6:1.2:1.1:0.9) Caenorhabditis elegans NDs Decrease ROS and MDA levels, increase SOD activity, restore MMP and ATP content, regulate DAF-16/FOXO pathways 2016
[26]
Pleurotus ostreatus POP / / D-Gal and AlCl3-treated Wistar rats AD Decrease MDA content, increase SOD, GPx and CAT activities in hippocampus, liver and serum 2016
[57]
Tricholoma lobayense TLH-3 4.23 Rha, Man, Glc-UA, Gal-UA, Glc, Gal and Ara (0.07:0.23:0.02:0.02:1.57:1:0.11) t-BHP-exposed HELF cells; D-Gal-treated Kunming mice Aging Decrease ROS level and inhibit oxidative damage induced by tert-butylhydroperoxide in HELF cells; decrease MDA content and increase SOD and CAT activities in mouse liver and serum 2016
[55]
Auricularia auricula-judae APP1-a 206 Rha, Ara, Xyl, Man, Glc and Gal (0.2:2.6:0.4:3.6:1.0:0.4) D-Gal-treated Kunming mice Aging Decrease MDA content, increase SOD and GPx activities in liver, serum and heart 2011
[58]
Amanita caesarea ACPS 18.62 Xyl, Man, Gal and Glc L-Glu exposed HT22 cells; D-Gal and AlCl3-treated balb/c mice AD Modulate Nrf2 pathways 2019
[60]
Flammulina velutipes FVP / Man, Rib, Glc, Gal and Xyl (4.07:4.54:3.07:1:2.21) D-Gal induced Wistar rats AD Increase SOD, CAT and GPx levels, decrease MDA levels; anti-apoptosis 2018
[59]
Cantharellus cibarius CC2a
CC3
/ CC2a (Fuc, GlcN, Gal, Glc, Man)
CC3 (Glc, Man, Rib)
Human undifferentiated neuroblastoma cell line SH-SY5Y NDs Shown antioxidant capacity, effectively neutralize the negative changes induced by activators of glutamatergic
system (glutamate, NMDA, AMPA)
2018
[32]
Anti-amyloidogenic effects Pleurotus ostreatus POP / / D-Gal and Al-treated Wistar rats AD Decrease Aβ peptide formation and tau phosphorylation by elevating the expression of PP2A and by reducing the expression of APP, BACE1 and GSK3β 2016
[57]
Anti-neuroinflammation Ganoderma lucidum GLP 15 / BV2 microglia and primary mouse microglia; zebrafish AD Decrease pro-inflammatory cytokines and promotes anti-inflammatory cytokine expressions in BV-2 and primary microglia; attenuate microglial migration, morphological alterations and phagocytosis probabilities 2017
[71]
Antrodia camphorata APC / / 6-hydroxydopamine treated C57BL/6J mice PD Reduce the activation of NLRP3 and the expression of related inflammatory factors 2019
[72]
APC / / Dopaminergic neuron cell line MES23.5; 6-hydroxydopamine treated mice PD Inhibit ROS-NLRP3 signaling 2020
[73]
Amanita caesarea ACPS2 16.6 Gal, Glc and Man (35.40: 31.77: 29.47) APP/PS1 mice AD Reduce inflammatory cell infiltration in brains, decrease serum concentrations of TNF-α and IL-1β, regulate neuroinflammation by regulating Nrf2 signaling and inhibiting NF-κB activation 2021
[91]
Anticholinesterase activities Hericium erinaceus HE / / L-Glu-exposed PC12 cells; AlCl3 and D-Gal-treated
balb/c mice
AD Enhance the Ach and ChAT concentrations in mouse serum and hypothalamus 2016
[87]
Flammulina velutipes FVP / / Scopolamine-treated Wistar rats Cognitive impairment Elevate the expression of CaMK II and connexin 36, and then regulated the activities of ChAT and AChE to normalize the level of ACh 2015
[92]
Armillaria mellea AMPS / / L-Glu induced HT22 cell; AlCl3 and D-Gal-treated balb/c mice AD Increase Ach and ChAT concentrations, decrease AchE concentrations in serum and hypothalamus of mice 2017
[83]
Amanita caesarea ACPS 18.62 Xyl, Man, Gal and Glc L-Glu exposed HT22 cells; D-Gal and AlCl3-treated balb/c mice AD Decrease AchE levels, increase Ach and chAT levels, improve cholinergic neurotransmission 2019
[60]
Anti-apoptotic activities Pleurotus eryngii PEP / / PC12 Cells induced by β-Amyloid; aging rats Aging Decrease intracellular calcium levels, and attenuated the β-amyloid-mediated cell apoptosis in PC12 cells; decrease iNOS, and COX-2 levels in aging rats 2020
[93]
Armillaria mellea AMPS / / L-Glu induced HT22 cell; AlCl3 and D-Gal-treated balb/c mice AD enhanced cell viability, suppressed nuclear apoptosis, inhibited intracellular ROS accumulation, prevented caspase-3 activation, and restored MMP 2017
[83]
Tremella fuciformis TL04 2033 Rha, Man and Glc (1:5.04:1.87) Glu-induced differentiated PC12 cells NDs Enhance Bcl-2 levels, suppress Bax expression and cytochrome c release, decrease activities of caspase-3 caspase-8, caspase-9 2016
[84]
Amauroderma rugosum AR / / PC12 rat pheochromocytoma cells induced by 6-OHDA Neurotoxicity Upregulate the expressions of proapoptotic proteins and downregulate the Akt/mTOR and MEK/ERK dependent pathways 2021
[85]
Morchella importuna MIP H2O2-induced PC12 cells NDs Inhibit cell apoptosis via down-regulation of the NF-κB pathway and the p38-JNK pathway and activating of the ERK 2016
[94]
Anti-neurotoxicity activities Hericium erinaceus HE / / L-Glu induced PC12 Cells; AlCl3 and D-Gal-treated balb/c mice AD Increase cell survival, induce cell differentiation, block intracellular Ca2+ overload, inhibit ROS production and prevent MMP depolarization in L-Glu induced HT22 cell apoptosis model; reduce the apoptosis rate, Aβ deposition, oxidative damage, and p-Tau aggregations in the hippocampus of AD mouse 2016
[87]