Table 1.

Mutant forms and post-translational modifications of Pink1 and Parkin and their pathological mechanisms.

Protein	Mutation or Modification	Pathological Mechanism
Pink1	I368N	Impossibility of binding to the outer mitochondrial membrane
Pink1	p.Q456X	Decreasing of mRNA level
Pink1	p.G411S	Partial loss of kinase activity
Parkin	UBL domain (1)	Decrease in Parkin phosphorylation
Parkin	UBL domain (2)	Parkin degradation
Pink1	S-nitrosylation	Loss of kinase activity
Pink1	G309D	Accumulation of α-synuclein