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. 2022 Nov 19;14(11):2514. doi: 10.3390/pharmaceutics14112514

Table 2.

Therapeutic strategies to restore mitophagy in PD.

Therapeutic Compound Therapeutic Strategy Therapeutic Mechanism
Kinetin PINK1 activator Direct binding to the active site
Celastrol PINK1 activator Enhancing expression
Salidroside PINK1 activator Enhancing expression
No name Parkin activator Direct binding to the active site
USP30i USP30 inhibitor Direct binding to the active site