Table A1.
Summary of inventions of enteric capsules between 1942 and 2022.
| Publication 1 | Applicant | Priority | Composition 2 (Capsule; INNER SHELL of the Capsule; Outer Shell of the Capsule)/Technology |
|---|---|---|---|
| CN115068436 | Jiangsu Zodiac Pharmaceutical Co., Ltd. | 2022-06-23 | Inner shell (HPMC, and carrageenan, gellan gum, agar, and potassium ions); Outer shell (HPMCP, and Tween® 80) |
| CN112546016 | Zhejiang Wanli University | 2022-04-22 | Capsule (HPMCP, agar, potassium chloride, and Tween® 80 in ammonium) |
| CN114376982 | Guangdong Pharmacology University |
2022-01-18 | Inner shell (chitosan); Outer shell (Eudragit® L 100, and HPMC) |
| EP3881834 | Jiangsu Lefan Capsule Co., Ltd. |
2021-09-22 | Capsule (pullulan, carrageenan, glycerol, and SLS) |
| CN215875588 | Zhejiang Xinchang Kangping Capsule Co., Ltd. | 2021-08-30 | Capsule (gelated alginate)/Provided with a special positioning lock ring |
| CN112569204 | Hubei Humanwell Pharmaceutical Excipients Co., Ltd. | 2021-03-30 | Inner shell (HPMS, HPMC, and pullulan, guar gum, carrageenan, xanthan gum, agar, and emulsifier); Outer shell (HPMCP) |
| CN109846852 | Chongqing Hengsheng Pharmaceutical Capsule Co., Ltd. | 2021-02-26 | Capsule (HPMC, potassium chloride, calcium acetate/ carbonate/citrate, sodium alginate) |
| WO2022112422 | Capsugel®, France/ Belgium | 2020-11-25 | Inner shell (gelatin, starch, PVA, and HPMC); Outer shell (HPMCAS, HPMCP, CAP) |
| CN111467318 | Hubei Humanwell Pharmaceutical Excipients Co., Ltd. |
2020-07-31 | Inner shell (tragacanth, gellan gum, carrageenan, konjac gum, xanthan gum, guar gum, agar, and calcium ions, and emulsifier, and coated with chitin, and sodium carbonate) |
| KR102272658 | Suheung Capsule | 2020-05-26 | Capsule (gelatin, and methoxylamide pectin, and buffer, and emulsifier) |
| TW201912150 | Qualicaps® | 2019-04-01 | Capsule (HPMC, MC, HPC, and Eudragit® L, Eudragit® NE, Eudragit® NM, Eudragit® FS 30D and HPMCP, HPMCAS, CAP, and PVA, and plasticizer, and surfactant) |
| CN109528689 | Jiangsu Zodiac Pharmaceutical Co., Ltd. |
2018-12-24 | Inner shell (carrageenan, sesbania gum, maltitol, potassium chloride, PVAP); Outer shell (PVAP, and surfactant) |
| WO2019020134 | Novamed | 2017-07-24 | Capsule (HPMC, CMC, gelatin, and gellan gum, guar gum, tragacanth, agar, alginate) |
| CN106902093 | Huaqiao University | 2017-01-24 | Capsule (alginate, and gellan gum, xanthan gum, carragheen, konjac glucomannan, locust bean gum, guar gum, arabic gum, and potassium ions, and HPMC, HPC, CMC, HPS) |
| CN106924211 | Qingdao Blue Valley Pharmaceutical |
2017-01-18 | Inner shell (HPMC, and carrageenan); Outer shell (low acyl gellan gum, and calcium chloride, acetic acid, calcium lactate) |
| US2021220285 | Capsugel®, Belgium | 2016-07-22 | Capsule (HPMCAS, HPMCP, CAP, PVAP, and HPMC, and ammonia, ethanolamine) |
| KR102335455 | Shinetsu Chemical Co., Ltd. | 2016-07-12 | Capsule (HPMCAS, ammonia) |
| US9452141 | Dah Feng Capsule Co., Ltd. | 2015-05-01 | Outer shell (gellan gum, pectin, pullulan, HPMC, and potassium chloride) |
| CN104434870 | Shaoxing Kangke Capsule Co., Ltd. |
2015-03-25 | Capsule (gelatin, and SLS, and sodium alginate) |
| TWI587880 | Dah Feng Capsule Co., Ltd. | 2015-03-24 | Outer shell (gelatin/ poly triglucose, PVA, modified starch, HPMC, and gellan gum, carrageenan, and monovalent/ divalent salt) |
| CN104288120 | Shaoxing Kangke Capsule Co., Ltd. |
2014-10-16 | Capsule (HPMC, and pectin, and SLS, Tween® 80, and glycerol, PEG, and sodium alginate, agar, carrageenan) |
| CN103919752 | Lou Zhi | 2014-05-07 | Capsule (HPMCP, and PEG, glycerol, castor oil) |
| CN103520134 | Songlin Liu | 2013-10-29 | Capsule (HPMCP, and PPG, glycerol, castor oil) |
| CN103394093 | Chongqing Hengsheng Medicinal Capsules |
2013-08-11 | Capsule (HPMC, and carrageenan, and potassium chloride) |
| CN103394092 | Chongqing Hengsheng Medicinal Capsules |
2013-08-11 | Capsule (HPMC, and gellan gum, and calcium chloride) |
| CN103417511 | Chongqing Hengsheng Medicinal Capsules |
2013-08-11 | Capsule (HPMC, and carrageenan, and calcium chloride) |
| CN103432096 | Chongqing Hengsheng Medicinal Capsules |
2013-08-11 | Capsule (HPMC, and carrageenan and potassium citrate) |
| CN103330695 | Shaoxing Kangke Capsule Co., Ltd. |
2013-06-05 | Capsule (HPMC, and SLS, Tween® 80, glycerol, PEG, and sodium alginate, agar, carrageenan) |
| US10172803 | Capsugel®, Belgium | 2013-03-07 | Capsule (HPMC, and calcium stearate, magnesium stearate, carnauba wax, and guar gum, pectin, carrageenan, xanthan gum, locust bean gum, alginate, alginic acid, tamarind gum, glucomannan, agar, curdlan, gellan gum, collagen) |
| TWI554290 | Samsung Fine Chemicals | 2012-06-05 | Capsule (HPMC, HPMCP, and ammonia, sodium hydroxide, and potassium hydroxide) |
| JP2018058870 | Capsugel®, Belgium | 2012-05-02 | Capsule (Eudragit® L 100, Eudragit® S 100, Eudragit® RS 100, CAP, CAT, HPMCAS, HPMCP, HPMC, HEC, EC, HPC, CMC, MC, and sorbitan monoesters, sorbitan POE esters, glycerol, PEG, castor oil, SLS, TEC, triacetin); Other similar compounds are also listed. |
| US2015080479 | Son Jin Ryul, Park Eun Hee | 2012-03-26 | Capsule (HPMCP, and HPMC, and calcium hydroxide, and ammonia, sodium hydroxide, and potassium hydroxide, and TEC, triacetin, PEG, PPG, and surfactants) |
| EP3566698 | Capsugel®, Belgium | 2011-11-09 | Capsule (CAP, CAT, HPMCAS, CMEC, PVAP, and monovalent/divalent carbonates and hydroxides) |
| KR20120100305 | Samsung Fine Chemicals | 2011-03-03 | Capsule (HPMCP, and HPMC, and calcium hydroxide, and sodium hydroxide, potassium hydroxide, and hydrogenated corn syrup, TEC, triacetin, PEG, PPG) |
| EP3354335 | Capsugel®, Belgium | 2010-10-26 | Capsule (CAP, and HPMC, HPC, EC, MC, CMEC, HPMCAS, HPMCP, and sorbitan monoesters and POE esters, glycerol, PEG, glycol, ricin oleate, SLS, TEC, triacetin, and POE-POP-POE triblock polymers); Other similar compounds are also listed. |
| US9603933 | Son Jin Ryul, Baek Hyon Ho | 2010-10-21 | Capsule (HPMCP, and HPMC, and ammonia, sodium hydroxide, potassium hydroxide, calcium hydroxide, and SLS, sugar ester) |
| US8710105 | Son Jin Ryul, Baek Hyon Ho | 2010-06-11 | Capsule (HPMCP, HPMCAS, HPMC, MC, carrageenan, agar, sodium alginate, gellan gum, pectin, sodium hydroxide, ammonia, potassium hydroxide, calcium hydroxide) |
| US8852631 | Capsugel®, Belgium | 2009-09-24 | Capsule (gellan gum, and HPMC) |
| WO2011030952 | Samsung Fine Chemicals | 2009-09-11 | Capsule (gellan gum, and HPMCP, and HPMCAS, and HPMC, MC, and neutralizing agent) |
| CN101433526 | Shanghai Huiyuan Plant Capsule Co., Ltd. |
2007-11-13 | Outlet shell (HPS, carrageenan, and calcium chloride, sodium carbonate, and CA) |
| WO2009062356 | Shanghai Huiyuan Vegetal Capsule Co., Ltd. |
2007-11-13 | Capsule (PVAP acrylic resin, acetyl pullulan, CAP, 1, 2, 4-benzene tricarboxylic acid acetate, HPMCP, HPMC 1,2,4-benzenetricarboxylate, CAS, succinic acid, acetic acid, HPMC, and monovalent and divalent hydroxides and carbonates, and acetylated gellan gum, carrageenan, agar, pectin, sodium alginate, xanthan gum, scutellaria, paulownia gum, locust bean gum, red algae gum, tamarind gum, tara gum, sclerotium glucan, alginate, carbomers) |
| US2010113620 | Aston University | 2007-03-29 | Capsule (HPMC, and alginate, and gellan gum, sodium, and potassium ions, and PEG) |
| US6752953 | Yung Shin Pharmaceutical Co. |
2004-06-22 | Capsule (cellulose nitrate, CTA, CAP, MC, EC, HPC, HPMC, HPMCP, and Eudragit® L, Eudragit® S, Eudragit® E, Eudragit® RL, Eudragit® RS, and glycerin, PPG, PEG, DEP, DBP, DBS, TEC, acetyl TEC, acetyl TBC, triacyl glycerol, castor oil); Other similar compounds are also listed. |
| WO2004012701 | Ajit Singh, Meena Parashuraman |
2002-08-02 | Capsule (gelatin, and methacrylic acid copolymer, CAP, HPMCP, PVAP, and ammonia, sodium carbonate, sodium bicarbonate, sodium hydroxide, and TEC, DBP, DEP, benzyl phenyl formate, sorbitol, PEG) |
| US4138013 | Parke, Davis & Co. | 1976-08-27 | Capsule (HPMC, and CAP, gelatin, the copolymer of methacrylic acid, and methacrylic acid ester) |
| GB1529901 | Parke, Davis & Co. | 1975-04-17 | Capsule (gelatin and CAP, HPMCP, the copolymer of methacrylic acid with methacrylic acid ester) |
| DE2336807 | Parke, Davis & Co. | 1972-07-20 | Capsule (gelatin, and HPMCP with softener) |
| GB743014 | Kodak Ltd. | 1952-05-01 | Capsule (ethyl ether CP, CAP, both prepared in situ) |
| GB638284 | Parke, Davis & Co. | 1946-03-25 | Capsule (gelatin, and glycerol, and in situ prepared CAP, and sodium carbonate) |
| GB610538 | Gelatin Products Corp. | 1945-11-05 | Capsule (gelatin, and glycerol, in situ prepared CAP, and sodium carbonate) |
| US2390088 | Gelatin Products Corp. | 1942-09-24 | Capsule (gelatin, and glycerol, CAP, and sodium carbonate) |
1 Each patent has a unique patent number that allows it to be found in the patent database; 2 abbreviations of the compositions of capsules used in summary without previous explanation are alphabetically ordered in brackets (CA—cellulose acetate; CP—cellulose phthalate; CMC—carboxymethyl cellulose; CMEC—carboxymethyl ethyl cellulose; DBP—dibutyl phthalate; DBS—dibutyl sebacate; DEP—diethyl phthalate; HEC—hydroxyethylcellulose; HEP—hydroxyethyl starch; HPS—hydroxypropyl starch; MC—methylcellulose; PEG—polyethylene glycol; POE—polyoxymethylene; POP—polyoxypropylene; PPG—propylene glycol; SLS—sodium lauryl sulfate; TBC—tributyl citrate; TEC—triethyl citrate).