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. 2022 Nov 21;17:5511–5524. doi: 10.2147/IJN.S381815

Figure 4.

Figure 4

Articular cartilage protection of KGN-MNPs. (A) H&E and Safranin O and fast green staining of sagittal sections of the medial tibial plateau. H&E staining showed that KGN-MNPs prevented the upward movement of the tidal line. Proteoglycan (red) and bone (green). (Scale bar= 250 μm). (B) OARSI scores. (C) Mankin scores. (D) Serum COMP levels. (E) Serum CTX-II levels. *p<0.05, **p<0.01.

Abbreviations: ns, not significant; KGN, kartogenin; MNPs, magnetic nanoparticles; Mag, magnet; KGN-MNPs, KGN-loaded MNPs.