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. 2022 Nov 21;17:5511–5524. doi: 10.2147/IJN.S381815

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© 2022 Jiang et al.

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KGN-MNPs normalize subchondral bone after anterior cruciate ligament transection. (A and B) Representative micro-CT images of longitudinal views of subchondral bone medial compartment. (Scale bar= 500 μm). Quantitative micro-CT analysis of tibial subchondral bone of BV/TV (C), Tb.pf (D), and Tb.th (E). Immunohistochemical (F) and quantitative (G) analyses of type X collagen in the calcified cartilage. (Scale bar= 100 μm). *p<0.05, **p<0.01.

Abbreviations: ns, not significant; KGN, kartogenin; MNPs, magnetic nanoparticles; Mag, magnet; KGN-MNPs, KGN-loaded MNPs.