Fig. 1.

B6.129S4(Cg)-Mapttm1(eGFP)Klt/J Mice (Tau^GFP/GFP mice). A) Fluorescence loupe image of a brain coronal section in a Tau^GFP/GFP and Tau^+/+ (wild type) mice. B) Gene Mapt schematic with GFP insertion in the first exon and (C) scheme of the resulting protein with the first 31 amino acids of tau protein followed by cytoplasmic eGFP protein that is expressed under the endogenous tau promoter. D) Representative fluorescence confocal microscopy images with different markers of glial cells as Olig2 (oligodendrocytes), Iba1 (microglia), GFAP (astrocytes), and NeuN (neurons) and their colocalization with the endogenous signal in Tau^GFP/GFP mice. Scale bar 10μm.