Table 1.
Final concentrations of RG–SG, RG, and their active constituents, ginsenosides Rb1, Rg3, Rg5, and Rk1 in the hippocampal neuronal cell line HT22, and of the number of deregulated genes (>20 fold compared to control).
| Sample Name | Concentration μg/mL |
Content in RG–RS Dry Extract, % |
Number of Deregulated Genes | Substance Specific Genes * |
|---|---|---|---|---|
| RG–RS | 20 (10/10) | 100 | 1151 | 1056 |
| RG | 10 | 50 | 397 | 397 |
| Rb1 | 0.0111–0.1 μM | 0.09 | 470 | 279 |
| Rg3 | 0.0785–0.1 μM | 2.15 | 413 | 236 |
| Rg5 | 0.0767–0.1 μM | 3.77 | 553 | 345 |
| Rk1 | 0.0767–0.1 μM | 2.0 | 373 | 214 |
| TT SA |
0.172–0.58 μM ** 0 |
0.86 0 |
n/a n/a |
n/a n/a |
TT—total tanshinones; SA—salvianolic acid B; *—gene numbers excluding those deregulated by RG; **—calculated as tanshinone II (MW 294.3).