Figure 1.

MUC1 expression in ccRCC specimens (A). Volcano plot of the 516 metabolites profiled; 116 exhibited significant differential abundance when comparing MUC1^H versus MUC1^L ccRCC (FC cut-off = 1.5 and p < 0.05) (B). Principal component analysis (PCA) of global tissue metabolome demonstrated that the three groups (MUC1^H tumors vs. MUC1^L tumors vs. normal renal tissues) were clearly distinguishable (C). Hierarchical clustering heatmap analysis of metabolites in normal, MUC1^H and MUC1^L cancer tissues (D).