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Colonization of spleen after intraperitoneal inoculation of 16M. Immunized mice (striped bars) received WR201. Nonimmunized animals (stippled bars) received saline intraperitoneally 9 weeks before intraperitoneal challenge with 105 16M. Spleens were harvested at the indicated time points, and number of CFU was determined in disrupted tissue by serial dilution and plating.
