Figure 2.

Evaluation of the administration of PFK15 ((E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one) and sunitinib, alone or combined, on HUVEC migration. HUVEC were treated with PFK15 at 5 (A) and 10 µM (B) and sunitinib at 0.1 and 1 µM for 8 h and changes in cell migration were analyzed. Statistical differences among groups were determined by one-way ANOVA followed by Tukey’s post hoc test. Data are presented as the mean ± SEM of three independent experiments performed in quadruplicate (** p < 0.01; *** p < 0.001).