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Synthesis pathways used to obtain 3β-O-Acetyl-30-(1H-1,2,4-triazole-3-ylsulfanyl)-betulinic acid (BA-TZ); TSC = thiosemicarbazide, TZ = 1,2,4-triazole-3-thiol, BA = betulinic acid, BrBA = 3β-O-Acetyl-30-bromo-betulinic acid; reaction conditions: a. reflux, 30 min; b. H2O, NaOH, reflux, 1h; c. acetic anhydride, pyridine, DMAP, r.t, 12h; d. NBS, CCl4, r.t, 48h; e. DMF, K2CO3, r.t, 72 h.
