FIG. 7.

Effect of multiple oral doses on tolerance. Responses of lymph node cells from mice not rendered tolerant (filled circles) or mice rendered tolerant with either a single dose of 1 mg (open circles), two doses of 1 mg each (open triangles), or three doses of 1 mg each (open squares) of OA are shown. Results of one experiment, representative of two for each group of mice, are shown. The oral doses were given 1 week apart for panels A and C and 14 weeks apart for panel B. Filled triangles and filled squares in panels A and B represent responses from control mice fed once or twice but not challenged s.c.