ARID1A’s functions (in black): transcriptional regulation (chromatin accessibility, epigenetic mark placement, RNAPII pausing regulation), PI3K/AKT/mTOR pathway regulation, cell-cycle regulation (p53 deacetylation through HDAC6), DNA repair: Homologous repair (HR) (RPA and RAD51 loading, ATR interaction, and activation), non-homologous end joining (NHEJ) (Ku70/Ku80 interaction), nucleotide excision repair (NER) (XPA interaction), miss match repair (MSS) (MSH2 interaction), Telomere regulation (STAG1 maintenance, TERT downregulation), oxidative stress repression (though SLC7A11 maintenance). ARID1A’s possible therapeutic options (in blue): cisplatin, PD-L1, PARP, ATR, YES1, BET (BRD2), HDAC6, HDAC2, EZH2, PI3K, AKT inhibitors, mTOR, MAPK inhibitors, ROS inducers. The figure was generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.