Table 4.
Overview of CRC alterations other than ARID1A in ovarian cancer. OC—ovarian cancer, SCCOHT—small cell ovarian carcinoma, hypercalcemic type, OCCC—Ovarian clear cell carcinoma, HGSOC—High-grade serous ovarian cancer.
| Chromatin Remodeler Complex | Gene | Change | Type of OC | References |
|---|---|---|---|---|
| SCCOHT | [133] | |||
| SWI/SNF | SMARCA4 | Inactivating mutation | OCCC | [94] |
| Dedefenrentiated OC | [93] | |||
| SWI/SNF | SMARCB1 | Inactivating mutation | SCCOHT | [95] |
| Epigenetic silencing, downregulation | SCCOHT | [134] | ||
| SWI/SNF | SMARCA2 | Inactivating mutation | OCCC | [94] |
| SWI/SNF, ISWI | SMARCA1 | Inactivating mutation | OCCC | [94] |
| SWI/SNF | BCL11A | Inactivating mutation | OCCC | [94] |
| SWI/SNF | DPF1 | Inactivating mutation | OCCC | [94] |
| Inactivating mutation | OCCC | [94] | ||
| SWI/SNF | SMARCC1 | Protein methylation by upregulated CARM1 | HGSOC | [96] |
| SWI/SNF, INO80 | ACTL6A | Amplification | Non-specified OC | [97] |
| SWI/SNF | BRD9 | Amplification | Non-specified OC | [97] |
| ISWI | RSF1 | Amplification, gene fusion | HGSOC | [27,104] |
| ISWI | CHARC1 | Amplification | HSGOC | [27] |
| ISWI | RBBP4 | Amplification, gene fusion | HSGOC | [27] |
| CHD | CHD5 | Inactivating mutation, promoter methylation | Non-specified OC | [113,116] |
| CHD | CHD8 | Amplification | HSGOC | [117] |
| CHD | CHD4 | mRNA overexpression | Non-specified OC | [119] |
| INO80 | RUVBL1 | Polymorphisms | Epithelial OC | [130] |
| INO80 | YY1 | Protein overexpression | Epithelial OC | [129] |