Table 2.
Comparison of variable amino acid sequences related to vaccine protection.
| Variable Residue 1 | 2.3.2.1 | 2.3.4.4 | ||
|---|---|---|---|---|
| Vaccine Strain 2 | Challenge Strain | Vaccine Strain 2 | Challenge Strain | |
| rgCA2/2.3.2.1d | CA/2.3.2.1 | rgES3/2.3.4.4h | ES2/2.3.4.4 | |
| 69 | E | E | E | E |
| 71 | T | I | I | I |
| 83 | A | A | L | L |
| 95 | F | F | A | A |
| 133 | S | S | A | S |
| 140 | N | N | V | V |
| 162 | I | I | I | I |
| 183 | D | D | A | A |
| 189 | R | R | L | L |
| 194 | P | P | T | T |
| 270 | E | E | E | E |
| Homology 3 (%) | 97.0 | 95 | ||
1 H5 numbering, including the signal peptide. 2 Reverse genetics vaccine strain, including the synthetic consensus H5 HA sequence. 3 Homology between vaccine and challenge strains barring the cleavage site sequences.