Figure 1.

Common MET driver mutations impact principally the juxtamembrane and kinase domains (exon 14). Lolliplot of MET protein domains (Sema, PSI, TIG, juxtamembrane, and Pkinase) showing common driver mutations identified in solid tumors from Table 1. Additionally, the protein structure shows the cancer hotspot (yellow circle), OncoKB prediction therapies (blue circles), exons numbered (blue and light blue rectangles), and protein topology. Yellow is the extracellular region, red, the cytoplasmic region, and, gray, the transmembrane region.