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In vitro VGFER-2 inhibition, cytotoxicity, and safety of the target compound 10.
| HepG2 IC50 (µM) |
SI (HepG2) | MCF-7 IC50 (µM) |
SI (MCF-7) | W-38 IC50 (µM) |
VEGFR IC50 (nM) | |
|---|---|---|---|---|---|---|
| Compound 10 | 21.00 | 1.55 | 26.10 | 1.25 | 32.57 | 65.83 |
| Sorafenib | 5.96 | 2.77 | 8.45 | 1.95 | 16.49 | 61.65 |
