Table 1.
In vitro characterization of ALN gel formulations.
| Formulation Code |
X1 | X2 | X3 | Y1 (%) (Mean ± SD) |
Y2 (nm) (Mean ± SD) |
Y3
(Mean ± SD) |
|---|---|---|---|---|---|---|
| F1 | 14.9 | 2:1 | 1:0.1 | 22.32 ± 0.84 | 349.80 ± 4.51 | 0.710 ± 0.01 |
| F2 | 14.9 | 1:1 | 1:0.1 | 28.82 ± 4.30 | 330.23 ± 10.05 | 0.610 ± 0.02 |
| F3 | 14.9 | 1:2 | 0 | 17.53 ± 1.10 | 395.33 ± 8.60 | 0.730 ± 0.02 |
| F4 | 4.7 | 1:2 | 1:0.1 | 5.97 ± 1.05 | 175.50 ± 17.12 | 0.253 ± 0.03 |
| F5 | 9.8 | 1:2 | 1:0.1 | 46.32 ± 0.84 | 192.43 ± 2.52 | 0.303 ± 0.02 |
| F6 | 14.9 | 1:2 | 1:0.1 | 66.52 ± 0.57 | 269.30 ± 9.58 | 0.331 ± 0.01 |
| F7 | 14.9 | 1:2 | 1:0.2 | 48.76 ± 0.45 | 343.07 ± 16.07 | 0.523 ± 0.01 |
X1: HLB; X2: non-ionic surfactant: cholesterol molar ratios; X3: dihexadecyl phosphate: non-ionic surfactant molar ratios. Y1: % EE; Y2: vesicle size; Y3: Poly Dispersity Index. SD: standard deviation.