Figure 4.

Inhibition of hKv1.3 currents by tagged recombinant Vm24, AnTx, and Ts6. These peptides are indicated in the figure as Tag-Vm24, Tag-AnTx, Tag-Ts6. Whole-cell currents through hKv1.3 were evoked from activated human peripheral T lymphocytes by depolarization to +50 mV from a holding potential −120 mV for 15 ms duration. Test pulses were applied every 15 s. Representative traces show the K⁺ current before the application of toxin (control) and after reaching the equilibrium block in the presence of Tag-Vm24 (blue), Tag-AnTx (green), and Tag-Ts6 (purple).