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Mean facial redness and pigmentation in the oral, combined and topical groups at 1 week, 4 weeks, and 8 weeks, relative to the baseline. (A) Mean facial redness in the oral, combined and topical groups at 1 week, 4 weeks, and 8 weeks, relative to the baseline. (B) Mean facial pigmentation in oral, combined, and topical at 1 week, 4 weeks, and 8 weeks, relative to the baseline. * p < 0.05; and *** p < 0.001.
