Table 2.

Main hypersensitivity studies and their characteristics found through our research.

Author	Date	Refineries Sites	Cohort	Age	Distance from Refineries	Exposure Time	Observational Time	Outcome in Exposed Groups
Smargiassi et al. [97]	July-14	Montreal, Quebec	72 recruited	Children (8–12)	NS	NS	10 days	Suggestion for a small ↓ in respiratory function with total concentrations of PAHs
Wichmann et al. [98]	March-09	La Plata, Argentina	1212 recruited	Children (6–12)	~10 km	NS	2005–2006	↑ Prevalence of asthma, ↑ asthma exacerbations, ↑ respiratory symptoms
De Moraes et al. [99]	August-10	Rio Grande do Norte, Brazil	209 recruited	Children (0–14)	within a 5-km radius	at least one year	1 year (2006)	↑ Frequency of respiratory symptoms
Rusconi et al. [100]	February-11	Sarroch, Sardinia	300 recruited	Children (6–14)	NS	NS	January–June 2007	↓ Lung function, ↑ markers of bronchial inflammation and oxidative DNA damage, ↑ MDA–dG adduct values
Idavain et al. [101]	February-19	Ida-Viru county, Estonia	1326 recruited	Children (8–12)	NS	NS	NS	↑ Prevalence of respiratory symptoms and of high fractional exhaled NO (FeNO) values (≥30 ppb)
Orru et al. [102]	February-18	Ida-Viru County, Estonia	5250 recruited	Adults (18–70)	NS	NS	2001–2013	↑ Frequency of wheezing, chest tightness, shortness of breath, asthma attack, long-term cough, cardiovascular diseases and diabetes in oil shale workers compared with exposed residents
Tanyanont et al. [105]	January-12	Map Ta Phut Municipality, Thailand	24.980 recruited	All (>13)	10 km radius	at least 1 year	September 2006–August 2007	↑ Frequency of all acute respiratory symptoms among residents living < 5 km, ↑ risk of dyspnea and wheezing in residents longer than 5 years near the industrial complex
Rovira et al. [106]	August-14	Tarragona county, Catalonia, Spain	5.196 recruited	Children (6–7; 13–14)	10 km	NS	2010	Not found higher prevalence of asthma, allergic symptoms and lower lung function. Significantly ↑ prevalence of respiratory hospitalizations and nocturnal cough