TABLE 3.

Histopathology data showing mean inflammatory scores of kidney, placental, and fetal tissues of E. coli Dr⁺- and E. coli Dr⁻-infected and control mice

Groupa	Inflammatory score (mean ± SEM) in tissueb
	Kidney						Placental tissue	Fetal tissue
	Renal pelvis		Tubular involvement		Interstitial involvement
	Acute	Chronic	Acute	Chronic	Acute	Chronic
Sacrificed after delivery
E. coli Dr+	2.12 ± 0.44c	1.50 ± 0.32c	0.62 ± 0.41	0	1.62 ± 0.32	1.12 ± 0.51	2.37 ± 0.32d	3.25 ± 0.25d
E. coli Dr−	0.25 ± 0.16	0.25 ± 0.25	0	0	0	0	0.62 ± 0.26	0.50 ± 0.26
Control	0	0	0	0	0	0	0	0
Sacrificed on day 17 of gestation
E. coli Dr+	0.75 ± 0.25e	1.87 ± 0.35e	0	0	0.25 ± 0.16e	0.37 ± 0.18e	ND	0.66 ± 0.42
E. coli Dr−	0.62 ± 0.41	1.25 ± 0.16	0	0	0.12 ± 0.12	0.37 ± 0.26	ND	0
Control	0	0	0	0	0	0	ND	0

^aHistopathology results in mice sacrificed after delivery were obtained from eight mice in each E. coli Dr⁺ and E. coli Dr⁻ group and six mice in the control group. Group sacrificed on day 17 of gestation included eight mice in the E. coli Dr⁺ group, eight mice in the E. coli Dr⁻ group, and five mice in the control group. 

^bHistopathologic evaluation was performed and scores were given as described in Materials and Methods under “Histological analysis of tissues.” ND, not determined. 

^cSignificantly different from the value obtained for the E. coli Dr⁻ group (P ≤ 0.001). 

^dSignificantly different from the value obtained for the E. coli Dr⁻ group (P ≤ 0.0001). 

^eNot significantly different from the value obtained for the E. coli Dr⁻ group (P > 0.05).