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. 2022 Nov 19;23(22):14373. doi: 10.3390/ijms232214373

Figure 3.

Figure 3

Markers of BBB integrity and permeability measured on BBB and BBB-H model. (A) TEER values of both models under HNE treatment (0, 10, 20, 40 µM). (B) Permeability of sodium fluorescein for both BBB models under HNE treatment (0, 10, 20, 40 µM). (C) Occludin and (D) claudin-5 changes in RbE4 cells of both BBB models at control conditions (0) and 20 µM HNE treatment, assessed by dot-blot. Signal intensities were analyzed with NIH ImageJ and represented as arbitrary units (AU). All results are represented as mean ± SD, n = 12 samples for each group from 4 independent experiments. a—statistically significant in respect to control (0) on pure collagen, p < 0.05; b—statistically significant in respect to control (0) on modified collagen, p < 0.01; c—statistically significant between groups of same treatment, p < 0.01.