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(a) Representation of the interaction of fluconazole (in green), a known triazole antifungal drug, with the heme group (in red) in the active site of CYP51 from Saccharomyces cerevisiae; (b) Representation of the interaction of VT-1161 (in green), a tetrazole antifungal agent, with the heme group (in red) in the active site of CYP51 from Candida albicans. ChemBio3D was used to visualize (PDB 4WMZ and PDB 5TZ, respectively) [25,26].
