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. 2022 Nov 3;14(11):2438. doi: 10.3390/v14112438

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Comparison of immunogenicity induced by one-dose and two-dose regimen of influenza vaccine in the elderly. (A) Comparison of immunogenicity induced by one and two doses of ID15 and SC15 at 21 days after the last immunization. The ratios of SPR, SCR, and GMT were calculated by dividing the mean SPR, SCR, and GMT after immunization with two doses by those after one dose. A ratio of <1 (dash line) implies lower immunogenicity of two-dose regimen than one-dose regimen. Similar calculations for GMT ratio were performed at 90 days (B) and 180 days (C) after the last immunization. Due to limited studies comparing the immunogenicity of one-dose versus two-dose regimen, a statistical test was not performed.