Table 5.
Resistant genotypes found in blood cultures and intra-abdominal samples, hospitals, patients involved, and molecular resistance mechanisms.
| Species | Genotype | Hospitals Involved |
Patients Involved |
No. of Isolates and Source | Phenotypic Resistance | FKSp Substitution | ERG11p Substitution | |
|---|---|---|---|---|---|---|---|---|
| Blood | Intra -Abdominal |
|||||||
| C. albicans | CA-0056 * | H9 | 1 | 0 | 1 | Echinocandin | F641L FKS1 HS1 | ND |
| CA-0511 | H6 | 2 | 1 | 1 | Echinocandin | S645P FKS1 HS1 | ND | |
| CA-1341 | H6 | 1 | 0 | 1 | Echinocandin | S645P FKS1 HS1 | ND | |
| CA-1872 | H2 | 1 | 1 | 0 | Echinocandin | R1361H FKS1 HS2 | ND | |
| CA-0313 ** | H1 | 1 | 1 | 0 | Fluconazole | ND | None | |
| CA-1283 | H7 | 1 | 1 | 0 | Fluconazole | ND | D115E, K128T, F145L, I471L/I | |
| CA-1505 | H2 | 1 | 0 | 1 | Fluconazole | ND | A114S, Y257H | |
| CA-1674 | H1 | 1 | 0 | 1 | Fluconazole | ND | None | |
| CA-1762 | H9 | 1 | 1 | 0 | Fluconazole | ND | D116E/D, D153E/D | |
| C. parapsilosis | CP-540 | H9 | 1 | 0 | 1 | Echinocandin | None | ND |
| CP-451 | H2, H4, H9, H15 | 39 | 37 | 2 | Fluconazole | ND | Y132F, R398I | |
| CP-673 | H4 | 2 | 2 | 0 | Fluconazole | ND | Y132F, R398I | |
| CP-674 | H4 | 2 | 2 | 0 | Fluconazole | ND | Y132F, R398I | |
| CP-675 | H10 | 5 | 4 | 1 | Fluconazole | ND | G458S | |
| C. tropicalis | CT-031 *** | H10 | 1 | 0 | 1 | Echinocandin | S654P/S FKS1 HS1 + V1352I/V, V1404I/V FKS1 | ND |
| CT-081 | H6 | 1 | 0 | 1 | Fluconazole | ND | None | |
| CT-313 | H7 | 1 | 1 | 0 | Fluconazole | ND | F449V | |
* Genotype also involving susceptible isolates found in hospitals H4, H9, H11, and H15; ** Genotype also involving a susceptible isolate found in hospital H5; *** Genotype also involving susceptible isolates found in hospitals H1 and H10. ND, Not done.