Table 1.
The prevalence of cases and age-standardized prevalence rate of non-rheumatic calcific aortic valve disease in 1990 and 2019, and their temporal trends from 1990 to 2019.
| 1990 | 2019 | 1990–2019 | 1990–2019 | |||
|---|---|---|---|---|---|---|
| Cases No. (95% UI) |
ASPR (per 100,000) No. (95% UI) |
Cases No. (95% UI) |
ASPR (per 100,000) No. (95% UI) |
ASPR Percentage Change (95% UI) |
AAPC No. (95% CI) |
|
| Global | 1,732,989 (1,431,469 to 2,074,809) |
45.54 (37.61 to 54.67) |
9,404,078 (8,079,604 to 10,889,727) |
116.34 (100.39 to 134.5) |
155.47 (141.66 to 171.7) |
3.36 (2.77 to 3.95) |
| Female | 838,493 (690,259 to 1,016,936) |
40.28 (32.99 to 48.82) |
4,376,817 (3,771,235 to 5,082,805) |
99.86 (86.1 to 115.88) |
147.89 (134.1 to 165.7) |
3.31 (2.86 to 3.75) |
| Male | 894,496 (741,593 to 1,067,498) |
51.19 (42.68 to 60.91) |
5,027,261 (4,276,877 to 5,861,586) |
133.38 (113.79 to 154.58) |
160.54 (146.7 to 176.16) |
3.38 (2.68 to 4.08) |
| High SDI | 1,324,934 (1,090,000 to 1,602,157) |
126.83 (104.61 to 152.72) |
5,095,444 (4,402,067 to 5,933,379) |
273.52 (237.08 to 315.22) |
115.66 (102.05 to 130.27) |
2.79 (2.18 to 3.41) |
| High-middle SDI | 364,934 (300,689 to 436,285) |
33.9 (27.98 to 40.44) |
3,569,820 (3,002,415 to 4,203,730) |
174.53 (147.33 to 204.54) |
414.83 (391.56 to 443.21) |
5.89 (5.55 to 6.23) |
| Middle SDI | 30,505 (24,085 to 37,764) |
2.82 (2.23 to 3.49) |
658,545 (529,926 to 800,781) |
25.93 (20.92 to 31.47) |
821.11 (709.87 to 944.23) |
8.04 (7.89 to 8.19) |
| Low-middle SDI | 9361 (7345 to 11,713) |
1.45 (1.15 to 1.79) |
67,258 (54,355 to 81,974) |
4.78 (3.86 to 5.82) |
229.82 (201.99 to 259.51) |
4.16 (4.08 to 4.24) |
| Low SDI | 2930 (2295 to 3719) |
1.12 (0.88 to 1.38) |
9675 (7605 to 12,135) |
1.67 (1.34 to 2.07) |
49.94 (44.14 to 56.39) |
1.39 (1.34 to 1.44) |
| High-income Asia Pacific | 469,556 (383,483 to 566,437) |
233.42 (191.41 to 280.25) |
1,715,700 (1,450,883 to 2,042,127) |
408.4 (348.93 to 479.89) |
74.96 (63.35 to 86.36) |
1.94 (1.8 to 2.08) |
| High-income North America | 687,664 (557,975 to 840,921) |
191.35 (155.87 to 232.93) |
1,492,891 (1,305,203 to 1,727,501) |
244.39 (214.46 to 279.6) |
27.72 (13.83 to 44.93) |
1.86 (0.81 to 2.92) |
| Western Europe | 218,212 (177,736 to 268,116) |
37.65 (30.75 to 45.97) |
1,862,787 (1,577,560 to 2,209,085) |
204.84 (174.62 to 240.59) |
444 (398.78 to 494.86) |
6.38 (5.73 to 7.03) |
| Australasia | 9877 (8177 to 11,826) |
41.77 (34.78 to 49.88) |
320,825 (272,234 to 381,057) |
649.5 (552 to 772.74) |
1454.86 (1236.35 to 1697.07) |
9.97 (9.85 to 10.08) |
| Andean Latin America | 831 (661 to 1026) |
3.77 (3.02 to 4.63) |
33,352 (28,251 to 39,016) |
59.04 (50.07 to 69.05) |
1465.67 (1241.46 to 1733.05) |
10.1 (9.49 to 10.72) |
| Tropical Latin America | 8034 (6435 to 9814) |
7.79 (6.23 to 9.54) |
58,601 (47,232 to 72,054) |
23.73 (19.16 to 29.01) |
204.51 (180.25 to 234) |
3.81 (3.7 to 3.92) |
| Central Latin America | 6996 (5589 to 8531) |
7.98 (6.44 to 9.71) |
76,957 (63,860 to 91,384) |
31.82 (26.45 to 37.75) |
298.86 (261.69 to 344.2) |
5.06 (4.14 to 6) |
| Southern Latin America | 5497 (4391 to 6936) |
11.87 (9.53 to 14.91) |
101,893 (87,124 to 120,797) |
122.72 (104.78 to 145.67) |
933.61 (766.84 to 1118.16) |
8.22 (8.07 to 8.38) |
| Caribbean | 3359 (2751 to 4009) |
12.61 (10.3 to 15.1) |
45,467 (37,694 to 54,849) |
87.51 (72.62 to 105.56) |
594.1 (504.42 to 696.1) |
7.07 (6.73 to 7.41) |
| Central Europe | 154,665 (128,343 to 184,574) |
104.18 (86.62 to 123.47) |
1,260,558 (1,067,648 to 1,479,616) |
608.31 (517.94 to 713.51) |
483.91 (434.98 to 537.45) |
6.63 (6.24 to 7.02) |
| Eastern Europe | 121,662 (97,120 to 148,877) |
43.32 (34.79 to 52.76) |
1,328,687 (1,065,696 to 1,605,206) |
395.8 (319.64 to 477) |
813.6 (752.33 to 886.02) |
8.12 (7.89 to 8.34) |
| Central Asia | 3767 (2956 to 4713) |
7.92 (6.22 to 9.83) |
41,060 (33,495 to 48,810) |
53.22 (43.89 to 62.92) |
572.13 (489.66 to 669.91) |
6.82 (6.7 to 6.93) |
| North Africa and Middle East | 9696 (7638 to 11,898) |
4.92 (3.9 to 6.04) |
54,300 (43,226 to 66,785) |
10.83 (8.67 to 13.35) |
120.05 (104.74 to 135.33) |
3.01 (2.55 to 3.47) |
| South Asia | 8332 (6398 to 10,638) |
1.34 (1.04 to 1.67) |
30,188 (23,678 to 37,633) |
2.03 (1.6 to 2.52) |
51.55 (45.4 to 58.54) |
1.44 (1.4 to 1.48) |
| Southeast Asia | 1785 (1337 to 2357) |
0.7 (0.53 to 0.91) |
23,986 (18,739 to 30,273) |
4.06 (3.21 to 5.09) |
480.45 (408.41 to 566.35) |
6.17 (6.05 to 6.29) |
| East Asia | 18,272 (13,682 to 24,325) |
2.1 (1.57 to 2.74) |
891,018 (707,255 to 1,093,313) |
42.41 (33.87 to 51.68) |
1920.64 (1545.86 to 2360.13) |
11.07 (10.58 to 11.57) |
| Oceania | 110 (89 to 136) |
4.3 (3.49 to 5.36) |
1130 (904 to 1374) |
18.61 (14.95 to 22.75) |
332.86 (271.32 to 396.31) |
4.7 (4.17 to 5.24) |
| Western Sub-Saharan Africa | 1300 (1004 to 1627) |
1.27 (0.99 to 1.58) |
3870 (3002 to 4876) |
1.65 (1.3 to 2.04) |
29.76 (25.16 to 34.98) |
0.85 (0.76 to 0.94) |
| Eastern Sub-Saharan Africa | 763 (589 to 963) |
0.93 (0.73 to 1.15) |
2602 (2004 to 3271) |
1.4 (1.1 to 1.74) |
51.64 (43.67 to 61.1) |
1.47 (1.41 to 1.53) |
| Central Sub-Saharan Africa | 245 (189 to 315) |
1 (0.79 to 1.26) |
796 (621 to 1012) |
1.36 (1.08 to 1.69) |
36.9 (28.71 to 46.73) |
1.12 (1.06 to 1.18) |
| Southern Sub-Saharan Africa | 2365 (1845 to 2936) |
8.15 (6.36 to 10.13) |
57409 (44,278 to 73,386) |
94.86 (72.97 to 120.7) |
1064.03 (877.48 to 1280.35) |
9.02 (8.62 to 9.41) |
AAPC, average annual percentage change; ASPR, age-standardized prevalence rate; SDI, socio-demographic index; UI, uncertainty interval; CI, confidence interval.