Table 1.

Recent research studies on curcumin-loaded nanoformulations for the treatment of wounds.

Components Incorporated	Formulation Developed	Characterization Techniques	In Vivo Model	Inference	Reference
Curcumin, carboxymethyl guar gum and reduced graphene oxide	Nanocomposites	FTIR, TGA, XRD	Rabbits	The proliferation of fibroblast cell lines 3T3-L1 resulted in 100 percent wound closure and regulated drug release. In addition, in vivo experiments revealed that the CMGG, rGO nanocomposite with curcumin had a wound-healing ability along with antibacterial, anti-inflammatory, and antioxidant effects.	[72]
Curcumin, chitosan, gelatin, PCL	Nanofibrous membrane	SEM, FTIR	Rats	It caused granulation tissue growth, collagen deposition, and epithelial tissue remodeling. It could also speed wound healing by facilitating the expression of CD31 and TGF- in the early stages of the wound, and improved antioxidant properties.	[73]
Curcumin loaded PCL/P VA-silk fibroin	Nanofibrous mat	SEM	Albino mice	Showed excellent antioxidant and anti-inflammatory action, along with accelerated wound-healing.	[74]
Curcumin, resveratrol, tween 80, and labrafac PG	Nanoemulsion	Particle size, PDI, zeta potential, reversed-phase HPLC analysis	Adult male Wister rats	In the skin of burnt rats, the developed formulation led to an increase in antioxidant and anti-inflammatory potential, as well as an increase in collagen and amino acid levels.	[75]
Zinc-Aluminium-LDH-Curcumin	Nanocomposite	TGA, DTA, XRD, FESEM, HRTEM, EDX	Adult male albino rats	Showed anti-inflammatory properties of both LDH and curcumin, as well as their biocompatibility with living matter, expanding their biomedical applications in this era with safety and efficacy through sustained drug release.	[52]
Curcumin, gelatin, sodium bicarbonate and honey	Nanofibrous membrane	SEM, FTIR	Wistar male albino rats	Accelerated the wound healing process by promoting re-epithelialization, proliferation of fibroblasts and providing anti-inflammatory action.	[76]
Surfactin, PCL gel and curcumin	Nanocomposite	FTIR, SEM, Wettability	Male Wistar rats	Increased curcumin’s bioavailability as an anti-inflammatory agent and accelerated different stages of wound healing. Furthermore, the produced dressings showed good bio-compatibility.	[77]
Heparin-PLGA Curcumin, EDC, and NHS	Nanofiber membrane	XPS analysis, water contact angle, WVTR, FE-SEM	Sprague Dawley (SD) rats	Increased hydrophilicity, resulting in faster cell migration and antioxidant activity.	[78]
Curucmin-loaded β-cyclodextrin, AgNPs chitosan, and polyethylene oxide	Nanofibers	Zeta potential, SEM, FTIR, AFM	Male Kunming mice	Stimulated skin wound healing by controlling angiogenesis and increasing proliferation of surrounding tissue, as well as reducing scar tissue formation.	[79]
CUR loaded CH/PEG/Ag	Nanoparticles	UV-Vis spectroscopy, XRD, FTIR, FESEM, TEM, TGA	Wistar albino rats	Developed formulation showed complete tissue regeneration, as well as the prevention of microbial infections in wounds, the quick healing of wounds, and the inhibition of apoptotic cell growth was observed.	[80]