Figure 4.

A, Each dot represents the average delay for each percentile of tract length. Blue dots represent controls, while red dots represent patients. B, Empirical cumulative distributions of the delays. The blue line corresponds to the average delays of the controls, while the red lines correspond to the average delays of the MS population. C, The violin plot shows the edgewise differences between delays in each patient and the average delay across all the controls for the corresponding edge. D, The vertical red line marks the observed average edgewise difference in the delays calculated only for delays that were lesioned. The distribution to the left shows the average delay difference observed after selecting a random sample based on a thousand randomizations of edgewise delay differences (i.e., ignoring the information about the structural integrity), with the size of each random sample equal to the number of lesioned edges. The results enabled us to reject the null hypothesis that edge-specific lesions would not affect the delays.