Table 3.

The clinical features of ALS patients with SYNGAP1 variant rs149438267

Sex	M	F	M	F	M	M	F
Age at onset	64	57	66	75	66	77	75
Clinical diagnosis based on the revised El Escorial criteria	Probable laboratory supported	Probable laboratory supported	Definite	Probable	Probable	Definite	Probable
Initial symptoms	Upper limb weakness	Upper limb weakness	Dysarthria	Upper limb weakness	Dysarthria, dysphagia, dyspnea	Dysarthria	Dysarthria
Duration from onset to death (month)	30	64	9	29 (censored observation)	7	18	38
Upper motor symptom	+	+	+	+	+	+	+
Lower motor symptom	+	+	+	+	+	+	+
Active denervation in EMG	+	+	+	+	+	+	+
Chronic denervation in EMG	+	+	+	+	+	+	−
Dementia	−	+	−	−	−	−	−
Cognitive tests	Not examined	MMSE 23, FAB 7	Not examined	MMSE 26, FAB 13	Not examined	MMSE 20, FAB 14	Not examined