Table 4.
Laboratory parameters at between baseline and 6 and 12 months for the treatment-naïve and switching groups.
| Parameter | Treatment Naïve | Switching Group | ||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 6 Months | 12 Months | p Value + | BASELINE | 6 months | 12 Months | p Value + | |
| HIV RNA, copies/mL | 18050.0 (4682.5, 45350.0) | 0.0 (0.0, 0.0) | 0.0 (0.0, 0.0) | 0.005 * | 2.13 ± 9.14 | 0.88 ± 4.43 | 1.33 ± 7.05 | 0.252 * |
| CD4, cells/uL | 445.5 (294.3, 560.8) | 620.0 (420.8, 887.5) | 666.5 (507.8, 912.3) | <0.001 | 692.50 ± 279.70 | 728.36 ± 293.71 | 703.66 ± 278.99 | 0.080 |
| CD8, cells/uL | 756.5 (614.5, 1059.0) | 813.5 (671.3, 1079.3) | 817.0 (664.0, 1013.0) | 0.583 | 805.98 ± 348.62 | 841.16 ± 356.35 | 784.05 ± 347.54 | 0.007 |
| Lipid profile | ||||||||
| Triglyceride, mg/dL | 89.0 (71.5, 139.5) | 126.5 (78.8, 159.3) | 92.0 (78.0, 196.5) | 0.135 | 188.91 ± 137.66 | 180.19 ± 115.32 | 161.52 ± 102.54 | 0.026 * |
| LDL, mg/dL | 106.4 (81.1, 122.9) | 104.1 (83.6, 129.6) | 107.3 (89.2, 120.0) | 0.993 | 109.70 ± 79.87 | 105.03 ± 31.75 | 103.96 ± 33.17 | 0.510 * |
| cholesterol, mg/dL | 172.5 (158.8, 202.3) | 178.0 (158.0, 212.8) | 181.0 (160.1, 202.8) | 0.719 | 184.62 ± 38.64 | 185.00 ± 36.56 | 177.70 ± 37.47 | 0.004 |
| Renal profile | ||||||||
| blood urea nitrogen, mg/dL | 12.0 (10.8, 15.2) | 15.0 (11.8, 16.4) | 14.7 (11.5, 15.8) | 0.088 | 14.64 ± 3.75 | 15.23 ± 3.94 | 15.12 ± 3.82 | 0.177 |
| creatinine, mg/dL | 0.9 (0.8, 1.0) | 1.0 (1.0, 1.1) | 1.1 (1.0, 1.2) | <0.001 | 0.99 ± 0.17 | 1.04 ± 0.16 | 1.02 ± 0.16 | <0.001 * |
| Liver function | ||||||||
| AST, IU/L | 23.0 (17.5, 33.5) | 20.0 (18.0, 30.0) | 23.0 (17.0, 29.3) | 0.342 * | 25.89 ± 22.65 | 24.53 ± 13.26 | 26.14 ± 10.77 | 0.511 * |
| ALT, IU/L | 26.5 (13.5, 32.3) | 21.0 (16.0, 24.0) | 21.0 (14.5, 35.0) | 0.283 * | 30.86 ± 30.23 | 29.28 ± 22.51 | 30.05 ± 20.32 | 0.726 * |
| Total bilirubin, mg/dL | 0.8 (0.5, 1.0) | 0.9 (0.7, 1.2) | 0.8 (0.6, 1.0) | 0.182 | 0.79 ± 0.40 | 0.89 ± 0.41 | 0.88 ± 0.35 | 0.003 |
| Glucose, mg/dL | 94.5 (90.5, 102.8) | 93.0 (87.3, 94.8) | 96.5 (89.0, 100.8) | 0.361 * | 104.85 ± 41.61 | 102.30 ± 19.11 | 105.05 ± 34.74 | 0.915 |
| Body weight, kg | 66.5 (62.3, 75.3) | 70.0 (64.0, 78.0) | 71.0 (64.0, 78.0) | 0.070 | 70.0 (63.3, 78.8) | 70.0 (63.0, 79.0) | 70.0 (63.2, 78.8) | 0.268 * |
Data are presented as median (Interquartile range), unless otherwise indicated. LDL; low density lipoprotein, HDL; high density lipoprotein, AST; aspartate aminotransferase, ALT; alanine aminotransferase. * Using Greenhouse-Geisser correction. + Using repeated measure ANOVA.