Table 2.
Serum cytokines concentrations at baseline. No statistical differences were observed among groups.
| All Subjects (n = 73) |
Group A (n = 24) |
Group B (n = 25) |
Group C (n = 24) |
|
|---|---|---|---|---|
| IL-6 (pg/mL) | ||||
| Baseline | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 0.99 (0.81–2.43) | 1.12 (0.81–1.57) | 2.33 (1.04–5.85) | 0.84 (0.81–3.02) |
| Min-Max | 0.81–6.81 | 0.81–2.38 | 0.82–6.81 | 0.81–4.64 |
| Week 4 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 0.92 (0. 81–1.84) | 1.40 (0.81–1.70) | 1.01 (0.81–1.64) | 1.19 (0.81–2.56) |
| Min-Max | 0.81–3.72 | 0.81–3.72 | 0.81–3.27 | 0.81–3.11 |
| Week 8 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 0.81 (0. 81–1.53) | 0.81 (0.81–1.17) | 0.89 (0.81–1.66) | 0.9 (0.81–2.28) |
| Min-Max | 0.81–2.55 | 0.81–2.55 | 0.81–1.89 | 0.81–2.51 |
| Week 12 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 0.81 (0. 81–1.18) | 0.81 (0.81–1.10) | 0.86 (0.81–1.57) | 0.95 (0.81–1.37) |
| Min-Max | 0.81–1.79 | 0.81–1.54 | 0.81–1.79 | 0.81–1.74 |
| IL-17A (pg/mL) | ||||
| Baseline | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 5.57 (4.45–13.38) | 5.54 (4.17–8.52) | 5.61 (3.87–10.60) | 9.92 (4.28–16.83) |
| Min-Max | 2.67–20.45 | 2.67–20.45 | 3.3–12.25 | 2.91–20.36 |
| Week 4 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 4.05 (2.32–11.43) | 3.71 (2.46–12.91) | 3.81 (2.3–8.79) | 7.03 (2.34–15.16) |
| Min-Max | 2.3–18.40 | 2.3–17.88 | 2.3–9.95 | 2.3–18.40 |
| Week 8 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 3.85 (2.30–10.48) | 3.85 (2.3–11.87) | 3.43 (2.3–4.63) | 6.18 (2.93–18.52) |
| Min-Max | 2.3–21.01 | 2.3–16.37 | 2.3–5.65 | 2.3–21.01 |
| Week 12 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 5.54 (2.50–13.66) | 5.88 (2.69–11.87) | 3.52 (2.3–15.17) | 9.41 (2.59–18.09) |
| Min-Max | 2.3–18.76 | 2.3–15.44 | 2.3–18.64 | 2.3–18.76 |
| IL-23 (pg/mL) | ||||
| Baseline | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 37.76 (20–45.45) | 37.76 (20–46.54) | 45.91 (24.62–57.36) | 34.11 (20–38.86) |
| Min-Max | 20–60.4 | 20–48.7 | 20–60.4 | 20–52.32 |
| Week 4 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 35.57 (20–41.28) | 35.57 (20–42.15) | 37.76 (23.71–36.48) | 35.57 (20–40.69) |
| Min-Max | 20–129.65 | 20–129.65 | 20–37.03 | 20–45.08 |
| Week 8 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 36.30 (20–42.63) | 36.3 (20–37.03) | 39.33 (23.89–53.67) | 38.13 (20–50.39) |
| Min-Max | 20–56.77 | 20–37.76 | 20–56.77 | 20–55.35 |
| Week 12 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 36.29 (20–40.32) | 35.66 (20–39.95) | 39.07 (24.55–39.77) | 34.11 (20–48.74) |
| Min-Max | 20–55.35 | 20–40.68 | 20–39.95 | 20–55.35 |
| IL-8 (pg/mL) | ||||
| Baseline | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 29 (29–34.27) | 29 (29–32.19) | 32.67 (29–52.29) | 29 (29–32.73) |
| Min-Max | 29–63.35 | 29–62.43 | 29–63.35 | 29–43.91 |
| Week 4 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 29 (29-39.17) | 35.33 (29–49.96) | 29 (29–39.86) | 29 (29–34.90) |
| Min-Max | 29–51.61 | 29–51.61 | 29–43.91 | 29–43.01 |
| Week 8 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 29 (29–35.34) | 29 (29–33.25) | 29 (29–32.98) | 33.76 (29–41.22) |
| Min-Max | 29–49.96 | 29–36.34 | 29–38.31 | 29–49.96 |
| Week 12 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 29 (29–41.69) | 29 (29–29) | 33.34 (29–42.58) | 39.01 (29–55.61) |
| Min-Max | 29–57.93 | 29–24.02 | 29–45.69 | 29–57.93 |
| IL-10 (pmol/L) | ||||
| Baseline | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 1.52 (0.98–1.81) | 1.27 (0.98–1.95) | 1.94 (1.13–2.44) | 1.25 (0.98–1.59) |
| Min-Max | 0.98–2.78 | 0.98–2.78 | 0.98–2.68 | 0.98–2.62 |
| Week 4 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 0.98 (0.98–1.82) | 0.98 (0.98–1.89) | 1.18 (0.98–2.48) | 1.31 (0.98–2.06) |
| Min-Max | 0.98–2.73 | 0.98–2.41 | 0.98–2.73 | 0.98–2.46 |
| Week 8 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 1.02 (0.98–2.28) | 1.02 (0.98–1.36) | 1.31 (0.98–4.66) | 1.56 (0.98–2.47) |
| Min-Max | 0.98–6.34 | 0.98–6.34 | 0.98–5.67 | 0.98–2.58 |
| Week 12 | ||||
| N | 73 | 24 | 25 | 24 |
| Median (IQR) | 0.98 (0.98–1.15) | 1.01 (0.98–2.32) | 0.98 (0.98–3.00) | 0.98 (0.98–1.24) |
| Min-Max | 0.98–3.86 | 0.98–3.86 | 0.98–3.64 | 0.98–1.29 |
Comparisons were performed between groups (A vs. B vs. C) by analysis of variance; IL = interleukin; IQR = interquartile range; SD = standard deviation.