Table 1.
Patient, disease and treatment characteristics and baseline HRQoL.
| Patient characteristics | |
| Average age, years (range), SD | 69 (39–91), 10.0 |
| Gender, n (%) | |
| Female | 149 (29.2) |
| Male | 361 (70.8) |
| Smoking status, n (%) | |
| Never smoker | 23 (4.5) |
| Ex-smoker before cancer diagnosis | 281 (55.1) |
| Ex-smoker, since cancer diagnosis | 88 (17.3) |
| Current | 115 (22.5) |
| Unknown | 3 (0.6) |
| Comorbidity, n (%) | |
| Cardio-vascular disease | 305 (59.8) |
| History of heart disease | 158 (31.0) |
| Hypertension | 251 (49.2) |
| COPD | 210 (41.2) |
| Depression | 61 (12.0) |
| Highest education, n (%) | |
| Primary school | 135 (26.5) |
| Secondary school | 84 (16.5) |
| Professional education | 46 (9.0) |
| University or equivalent | 52 (10.2) |
| Unknown | 193 (37.8) |
| Disease characteristics | |
| Disease stage, n (%) | |
| I | 169 (33.1) |
| II | 61 (12.0) |
| IIIA | 172 (33.7) |
| IIIB | 97 (19.0) |
| Unknown | 11 (2.2) |
| Histology, n (%) | |
| Adenocarcinoma | 194 (38.0) |
| Squamous cell carcinoma | 176 (34.5) |
| Large cell NOS and other types of NSCLC | 27 (5.3) |
| Unknown | 113 (22.2) |
| Treatment characteristics | |
| Radiation technique, n (%) | |
| 3D-CRT | 155 (30.4) |
| IMRT | 208 (40.8) |
| Rotational IMRT (including VMAT and tomotherapy) | 76 (14.9) |
| SBRT | 147 (28.8) |
| Combined treatment modality, n (%) | |
| Concurrent chemo-radiotherapy | 192 (37.6) |
| Sequential chemo-radiotherapy | 61 (12.0) |
| Radiotherapy alone | 257 (50.4) |
| Surgery, n (%) | 49 (9.6) |
| HRQoL baseline scores | |
| Physical functioning | 72.1 |
| Role functioning | 70.7 |
| Emotional functioning | 75.1 |
| Cognitive functioning | 83.5 |
| Social functioning | 79.7 |
| Fatigue | 34 |
| Nausea and vomiting | 7.8 |
| Pain | 16.7 |
| Dyspnoea | 35 |
| Insomina | 27.2 |
| Appetite loss | 20.6 |
| Constipation | 17.9 |
| Diarrhoea | 7 |
| Financial difficulties | 10.7 |
| Global health status/QoL | 52.7 |
| Overall HRQoL | 78.1 |
| Baseline overall HRQoL and domains per stage | |
| Stage I | |
| Physical functioning | 67.1 |
| Role functioning | 67.2 |
| Emotional functioning | 77 |
| Cognitive functioning | 82.7 |
| Social functioning | 81 |
| Overall HRQoL | 78.8 |
| Stage II | |
| Physical functioning | 69.1 |
| Role functioning | 72.2 |
| Emotional functioning | 74.9 |
| Cognitive functioning | 79.7 |
| Social functioning | 76.8 |
| Overall HRQoL | 77.4 |
| Stage IIIA | |
| Physical functioning | 75.7 |
| Role functioning | 73.7 |
| Emotional functioning | 76.9 |
| Cognitive functioning | 86.5 |
| Social functioning | 81.7 |
| Overall HRQoL | 79.8 |
| Stage IIIB | |
| Physical functioning | 75.3 |
| Role functioning | 71.7 |
| Emotional functioning | 71.6 |
| Cognitive functioning | 82.9 |
| Social functioning | 77.1 |
| Overall HRQoL | 76.5 |
Abbreviations: 3D-CRT, three-dimensional conformal radiation therapy; COPD, chronic obstructive pulmonary disease; HRQoL, health-related quality of life; IMRT, Intensity-Modulated Radiation Therapy; n, number; NOS, not otherwise specified; NSCLC, non-small cell lung cancer; SBRT, Stereotactic body radiation therapy; SD, standard deviation; QoL, quality of life; VMAT, Volumetric- Modulated Arc Therapy.