Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of the antitumor mechanism of MLD in HepG2 cells. MLD firstly caused mitochondrial damage and decreased the mitochondrial membrane potential, resulting in the production of ROS. The overproduction of ROS then increased BNIP3, inducing PI3K/AKT/MTOR-related mitophagy and GSDMD-related pyroptosis, leading to the induction of HepG2 cell death in vitro and in vivo.
