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Mean Facial Wrinkle Severity in the Control and PE Group, Relative to Pretreatment Baseline. The facial wrinkle severity was measured through the use of high-resolution imaging analysis of standardized photography. The average facial wrinkle severity decreased by 6.2 ± 1.6 (** p = 0.004) in the PE group and there was no statistical change in the control (placebo) group.
