Table 2.
Role of different miRNAs in developing chemotherapy resistance in different cancers.
| miRNA | Cancer Type | Drug | Target | References |
|---|---|---|---|---|
| miR-155 | Breast cancer | Doxorubicin, Paclitaxel, VP16 | FOXO3A | [40] |
| miR-200c | Trastuzumab | ZEB1, ZNF217 | [41] | |
| miR-125 a/b | Colon Cancer | Paclitaxel | ALDH1 | [42] |
| miR-200c | 5-fluorouracil | ZEB1/2 | [43] | |
| miR-451 | SN38, Irinotecan | ABCB1, COX2, ATF | [44] | |
| miR-29b | Cholangiocarcinoma | Gemcitabine | MMP-2 | [45] |
| let-7i | Ovarian Cancer | Cisplatin | PGRMC1 | [46] |
| miR-214 | Cisplatin | PTEN | [47] | |
| miR-181a/b | Leukemia | Fludarabine | BCL-2, XIAP MCL-1 | [48] |
| miR-181b | HMGB1, MCL-1 | |||
| miR-221/222 | Lung Cancer | TKIs, TRAIL | APAF1, TIMP3, PTEN | [49] |