Table 4.

In vivo results related to PFAS exposures and oxidative stress.

Publication Information	Study Setup
Authors	Species	Solvent	Body Weight	Fetal Weight	Offspring Weight	Rep/Dev	Amino acids	Glucose	Lipids	Liver	Oxidative Stress	Lethality	Specific Genes	Other AO
PFOS
Kim et al., 2020 [53]	C. elegans					↓	↑↓		↑↓		↑	↑
Kim et al., 2021 [54]	Drosophila	Aceton	↓			↓			↑↓			↑
Lee et al., 2015 [55]	Female CD-1 mice	DMSO							↑↓		↑
Li et al., 2020 [56]	Adult CD-1 mice	DMSO												DNA Methylation
Li et al., 2020 [57]	C. elegans	Water							↑↓
Ortiz-Villanueva et al., 2018 [58]	Zebrafish	DMSO					↑↓							Metabolome
Park et al., 2020 [59]	Macrophthalmus japonicus crab													Involvement of MAPK/p38
Qiu et al., 2016 [60]	Male ICR mice	DMSO	–									↑
Seyoum et al., 2020 [61]	Daphnia	Water	↓			↓			↑↓			↑
Wan et al., 2020 [62]	CD1 mice	DMSO		↓		↓							SNAT4
Wang et al., 2020 [63]	Dugesia japonica	DMSO									↑		SOD, CAT, GPx1
Xia et al., 2018 [64]	Anodonta woodiana	DMSO										↑
Yue et al., 2020 [65]	C. elegans	Water	↓			↓			↑↓			↑		Metabolism
Zhang et al., 2020 [66]	Manila clam	DMSO									↑↓			Metabolism/Genes
PFOA
Du et al., 2018 [67]	Male Balb/c mice	DMSO	↓					↑	↑			↑
Guruge et al., 2006 [68]	Male Sprague–Dawley rats		↑↓				↑↓		↑↓				Transcriptome	Gene expression
Kim et al., 2020 [53]	C. elegans					↓	↑↓		↑↓		↑	↑		Metabolism; Lipidomic
Li et al., 2019 [69]	Kunming mice			↓						↑↓	↑	↑		Gene expression
Li et al., 2021 [70]	M. edulis	Water									↑		CAT/SOD/GPx
Liu et al., 2015 [71]	Male mice	Water				↓					↑
Liu et al., 1996 [72]	Male rats	unclear	↓							↑
Salimi et al., 2019 [73]	Mouse		↓								↑
Seyoum et al., 2020 [61]	Daphnia		–			↓			↑↓			↑
Wang et al., 2010 [74]	Drosophila		↓		↓	↓								Reduced longevity of males
Xia et al., 2018 [64]	Anodonta woodiana	DMSO										↑
Yan et al., 2015 [75]	Male Balb/c mice	Water						↑↓	↑↓	↑↓			Akt, GSK
Yang 2010 [76]	Oryzias latipes	Water									–		PPR alpha

Rep/Dev, effects on reproduction and/or development; green cell (↑), increase; orange cell (↓), decrease; blue cell, changes in different directions; grey cell (–), no effect. For more details, see Supplementary Table S1.