Table 6.
In vivo results related to PFAS exposures and cellular signaling pathways.
| Publication Information |
Study Setup | Cellular Signaling | |||||
|---|---|---|---|---|---|---|---|
| Authors | Species | Target Tissue | P-AKT (Thr308) | p-AKT (S473) | P38 mRNA | PPARα mRNA | PPARγ mRNA |
| PFOS | |||||||
| Park et al., 2020 [59] | Crab (Macrophthalmus japonicus) | Gill, hepatopancreas | ↑ | ||||
| Qiu et al., 2016 [60] | Mouse (male ICR mice 8 weeks of age) | Testes | ↑ | ||||
| Xu et al., 2016 [86] | Mouse (C57BL/6 mice 10 weeks of age) | Epididymal white adipose tissue | ↑ | ||||
| Zhang and Sun et al., 2020 [66] | Clam (R. philippinarum) | Hepatopancreas | ↑ | ||||
| PFOA | |||||||
| Du et al., 2018 [67] | Mouse (male Balb/c mice 6–7 weeks of age) | Adipose tissue | ↓ | ||||
| Lu et al., 2016 [88] | Mouse (male Balb/c mice 6–8 weeks of age) | Epidymis | ↑ | ||||
| Yan et al., 2015 [75] | Mouse (male Balb/c mice 6–8 weeks of age) | Liver | ↑ | ↑ | |||
| Yan et al., 2015 [75] | Mouse (male Balb/c mice 6–8 weeks of age) | Muscle | ↑ | ||||
| Yan et al. 2015 [75] | Mouse (male Balb/c mice 6–8 weeks of age) | White adipose tissue | ↓ | ||||
| Yang 2010 [98] | Fish (male medaka fish) | Liver | ↑ | ||||
Green cell (↑), increase; orange cell (↓), decrease. For more details, see Supplementary Table S3.