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The mechanism of fascaplysin inhibiting the growth of NSCLC in vitro and in vivo. In vitro, fascaplysin induced apoptosis by promoting the elevation of ROS. It induced ferroptosis by modulating the GPX4 signaling pathway and provoked ER stress. In vivo, fascaplysin improved the sensitivity of anti-PD-1 immunotherapy, which in turn inhibited tumor growth.
