Shown are IL-1α levels in plasma (A) and in Peyer's patch tissue (B), IL-1β levels in plasma (C) and in Peyer's patch tissue (D), and IL-1ra levels in plasma (E) and in Peyer's patch tissue (F). Cytokine measurements were performed after 2, 4, and 8 h of infection either by invasive S. flexneri M90T (solid bars) or by its noninvasive-adhesive derivative, BS15 (shaded bars). The plasma was from blood samples taken from the mesenteric vein draining the infected loop containing the Peyer's patch. The data represent means plus standard deviations.