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The binding of epidermal growth factor (EGF) with EGFR activates the receptor signaling due to phosphorylation. It stimulates various intracellular kinases signaling such as PI3K, Ras, MAPK, mTOR and induces cell division, proliferation, and growth. It interferes with other cellular signaling, such as IGFR, ER. It shows crosstalk with ER, which is present on the membrane, simultaneously cell signaling starts and the formation of proteins.
